Initial d deja vu mv12/24/2023 ![]() ![]() Articles related to the d-dimer and VTE was taken into consideration to write this paper. We searched the PubMed database and reviewed the articles published until June 2011. ![]() Although the D-dimer has a high NPV, patients with positive D-dimer should undergo further imaging to determine whether or not they have VTE. The purpose of this test, which has a high negative predictive value (NPV), is to provide a fast and cost-effective way to triage patients with thromboembolic phenomenon. D-dimer is detectable in patients with deep venous thrombosis (DVT), as it is a marker of endogenous fibrinolysis. The new cutoff values of D-dimer testing were analyzed in a recent prospective study of pregnant women they are 286 ng DDU/ml, 457 ng DDU/ml, and 644 ng DDU/ml for the first, second, and third trimesters, respectively.ĭ-Dimer is used as an initial screening test in the emergency department to diagnose patients who have signs, or symptoms suggestive of venous thromboembolism (VTE). Among oncology patients, D-dimer testing has the highest sensitivity and NPV in excluding VTE. Studies performed after a negative D-dimer for 3 months proved the high negative predictive value (NPV) of D-dimer testing together with LCP in patients with suspected VTE. Patients with high D-dimer levels upon presentation may prompt a more intense diagnostic approach, irrespective of pretest probability. Many previous studies have shown that the D-dimer test is highly sensitive (>95%) in acute deep venous thrombosis or pulmonary embolism, usually with a cut-off value of 500 μg FEU/l, which reasonably rules out acute VTE, particularly in patients with low clinical probability (LCP) or intermediate clinical probability. Many factors play a key role in changing the sensitivity and specificity of D-dimer testing, including the extent of thrombosis and fibrinolytic activity, duration of symptoms, anticoagulant therapy, comorbidity due to surgical or medical illnesses, inflammatory diseases, cancer, elderly age, pregnancy and the postpartum period, and previous VTE. Articles related to the D-dimer and VTE were considered to write this paper. ![]() Venous thromboembolism (VTE) is the leading cause of morbidity and mortality among hospitalized patients. ![]()
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